عندما كان الطبيب روحا وعقلا وكانت علاقة الطبيب بالمريض كعلاقة الروح بالعقل كانت منتديات الروح والعقل


    Neuroprotective effect of magnesium sulfate

    شاطر

    Dr:Sonia
    المدير العام
    المدير العام

    انثى
    عدد المشاركات : 447
    رقم العضوية : 1
    المستوى : GP
    الاقامة : الخرطوم- السودان
    نقاط النشاط : 9469
    السٌّمعَة : 15
    تاريخ التسجيل : 27/10/2008

    حصرى Neuroprotective effect of magnesium sulfate

    مُساهمة من طرف Dr:Sonia في الأحد 14 ديسمبر 2008, 9:38 pm

    TI A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy.
    AU Rouse DJ; Hirtz DG; Thom E; Varner MW; Spong CY; Mercer BM; Iams
    JD; Wapner RJ; Sorokin Y; Alexander JM; Harper M; Thorp JM Jr; Ramin
    SM; Malone FD; Carpenter M; Miodovnik M; Moawad A; O'Sullivan MJ;
    Peaceman AM; Hankins GD; Langer O; Caritis SN; Roberts JM
    SO N Engl J Med. 2008 Aug 28;359(9):895-905.




    BACKGROUND: Research suggests that fetal exposure to magnesium sulfate before preterm birth might reduce the risk of cerebral palsy. METHODS: In this multicenter, placebo-controlled, double-blind trial, we randomly assigned women at imminent risk for delivery between 24 and 31 weeks of gestation to receive magnesium sulfate, administered intravenously as a 6-g bolus followed by a constant infusion of 2 g per hour, or matching placebo. The primary outcome was the composite of stillbirth or infant death by 1 year of corrected age or moderate or severe cerebral palsy at or beyond 2 years of corrected age. RESULTS: A total of 2241 women underwent randomization. The baseline characteristics were similar in the two groups. Follow-up was achieved for 95.6% of the children. The rate of the primary outcome was not significantly different in the magnesium sulfate group and the placebo group (11.3% and 11.7%, respectively; relative risk, 0.97; 95% confidence interval [CI], 0.77 to 1.23). However, in a prespecified secondary analysis, moderate or severe cerebral palsy occurred significantly less frequently in the magnesium sulfate group (1.9% vs. 3.5%; relative risk, 0.55; 95% CI, 0.32 to 0.95). The risk of death did not differ significantly between the groups (9.5% vs. 8.5%; relative risk, 1.12; 95% CI, 0.85 to 1.47). No woman had a life-threatening event. CONCLUSIONS: Fetal exposure to magnesium sulfate before anticipated early preterm delivery did not reduce the combined risk of moderate or severe cerebral palsy or death, although the rate of cerebral palsy was reduced among survivors. (ClinicalTrials.gov number, NCT00014989.)





    AD University of Alabama at Birmingham, Birmingham, USA. drouse@uab.edu
    PMID 18753646

      الوقت/التاريخ الآن هو الأحد 04 ديسمبر 2016, 8:18 pm